Nature · Cover story
PsychAD makes the cover of Nature
Our population-scale atlas opens a new window into the human brain, across eight disorders.
Human brains. Cellular discoveries.
Understanding
the brain.
One cell at a time.
We connect single-cell genomics, human genetics and machine learning to understand what makes the brain vulnerable—and resilient—to disease.
In the spotlight
Science worth sharing.
Nature Genetics · Cover story
FreshMG on the cover of Nature Genetics
Revealing the remarkable plasticity of the brain’s immune cells in aging and Alzheimer’s disease.
The questions that drive us
A clearer picture
of a complex brain.
Brain disorders don’t affect every cell in the same way. We study the differences to reveal the genes, cell states and regulatory programs that shape human health.
01
Population-scale single-cell atlases
What changes in each cell type across brain disorders—and what do those disorders share?
Discover more 02Microglia & brain immunity
How do the brain’s immune cells change with age and Alzheimer’s disease?
Discover more 03Cell-type-specific genetics
In which cells do genetic risk variants for brain disorders exert their effects?
Discover moreAlso exploring machine learning and gene regulatory networks.
Our research directionsDiscovery at population scale
Every cell tells
part of the story.
The PsychAD atlas brings brain disorders into a shared cellular map—connecting molecular changes across people, cell types and diagnoses.
Inside the atlas
6.3MNuclei in the PsychAD atlas
1,494Brain donors
65Cell subtypes
8Brain disorders compared
Made possible by brain donors, their families and our collaborators. Read the study
A collaborative science
Big ideas.
Shared discoveries.
We are computational biologists, geneticists and neuroscientists working together at Mount Sinai in New York City. As part of the Center for Disease Neurogenomics, we turn rich human datasets into new biological questions.
From the lab
Selected publications
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Single-cell atlas of transcriptomic vulnerability across brain disorders
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Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease
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Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution
Paper
doi:10.1038/s41597-025-04687-5